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Updated: Oct 4, 2025

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Coding and long non-coding gene expression changes in the CNS traumatic injuries.

Xizi Wu1,2, Haichao Wei1,2, Jia Qian Wu3,4,5

  • 1The Vivian L. Smith Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.

Cellular and Molecular Life Sciences : CMLS
|February 7, 2022
PubMed
Summary
This summary is machine-generated.

Long non-coding RNAs (lncRNAs) are key players in central nervous system (CNS) injuries like traumatic brain injury (TBI) and spinal cord injury (SCI). These molecules offer potential new targets for diagnosing and treating CNS damage.

Keywords:
Gene expressionLong non-coding RNAs (lncRNAs)RNA-sequencing (RNA-Seq)Spinal cord injury (SCI)Traumatic brain injury (TBI)

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genomics

Background:

  • Traumatic brain injury (TBI) and spinal cord injury (SCI) are severe central nervous system (CNS) traumas with limited therapeutic options.
  • Gene expression profiling reveals significant alterations in coding and non-coding genes following CNS injury.

Purpose of the Study:

  • To review recent advances in transcriptome studies of SCI and TBI.
  • To explore the molecular mechanisms of long non-coding RNAs (lncRNAs) in CNS injury.
  • To highlight the potential of lncRNAs as diagnostic and therapeutic targets.

Main Methods:

  • Analysis of bulk RNA sequencing (RNA-Seq) and single-cell RNA-Seq (scRNA-Seq) data.
  • Review of gain- and loss-of-function studies on lncRNAs in CNS injury models.
  • Examination of lncRNA regulatory roles in inflammation, glial activation, apoptosis, and vasculature.

Main Results:

  • lncRNAs exhibit tissue- and cell type-specific expression patterns in the CNS.
  • lncRNAs modulate protein-coding genes and microRNAs (miRNAs) involved in injury responses.
  • lncRNAs play critical roles in inflammation, glial activation, cell apoptosis, and vascular events post-injury.

Conclusions:

  • lncRNAs are significantly implicated in the molecular pathology of TBI and SCI.
  • lncRNAs represent promising biomarkers for diagnosis and prognosis.
  • lncRNAs offer novel therapeutic targets for managing CNS injuries.