Hyperemesis gravidarum and risks of placental dysfunction disorders

To investigate the association between hospitalisation of cases affected during the first and second trimester of pregnancy with the increased intrapartum complication attributed to placental dysfunction disorders. Additionally to highlight the distinct maternal factors and foetal morbidity patterns for improving the obstetrical outcome.

An observational study was carried out in Al-Yarmouk Hospital, Baghdad, Iraq from the 1st December 2019 to end December, 2020, recruiting 250 singleton pregnancy of gestational age >10 to >21 completed weeks until delivery. Patients were grouped into two; taking gestational age on admission as a divider; group1 < 10 weeks and group 2 > 12 weeks till completed 21weeks. Participants had at least one hospitalisation for this diagnosis. After a detailed history and examination and recording associated maternal morbidities, including hypertension, hyperthyroidism and diabetes; furthermore, we excluded intrapartum complications as Prematurity, abnormality in foetal weight including stillbirth and preeclampsia risk.

None of the demographic criteria nor maternal morbidity factors were significant on analyses. Conversely, all intrapartum complications were significantly higher in both recruited groups.

The strong relationship between hyperemesis gravidarum and placental dysfunction related complications highlight admitted HG cases as a higher risk group; being liable for severe foetomaternal morbidities, demanding more surveillance for a better outcome.