Increased serum amyloid A and C- Reactive Protein in preterm labour women: A case control study

To assess the possible relation between serum Amyloid A and pregnant women presenting with preterm births.

The retrospective case-control study was conducted at Al-Yarmouk Teaching Hospital, Baghdad, Iraq, and comprised data from December 1, 2019, to December 1, 2020, of patients who presented with preterm labour with gestational age 28-37 weeks. Data of similar women with complication-free pregnancy was taken to raise the control group. Serum samples were taken from the subjects at admission before any intervention for the measurement of serum amyloid A, total white blood cells, C-reactive protein, and neutrophil-leukocytes ratio. Data was analysed using SPSS 25.

Of the 100 subjects, 50(50%) were in each of the two groups that had no significant differences regarding age, gravida, parity, smoking, and neutrophil-leukocytes ratio (p>0.05). There were significant inter-group differences regarding serum amyloid A and C-reactive protein levels (p<0.05). The cut-off value for serum amyloid A level was 84.61ng/ml. There was a positive correlation between micro-C-reactive protein and serum amyloid A (p<0.05).

Maternal serum amyloid A level in the 2nd trimester may be a predictive marker for preterm labour.