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Auditory nerve phase-locked response recorded from normal hearing adults using electrocochleography.

Hana A Almohammad1, Mark E Chertoff2, John A Ferraro3

  • 1Department of Rehabilitation Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.

International Journal of Audiology
|February 7, 2022
PubMed
Summary

The auditory nerve overlapped waveform (ANOW) response offers a reliable, non-invasive method for assessing low-frequency hearing. This new objective measure demonstrates higher robustness with lower stimulus frequencies, promising improved hearing threshold accuracy.

Keywords:
Phase lockingelectrocochleographyelectrophysiologypsychoacoustics/hearing science

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Area of Science:

  • Audiology
  • Neuroscience
  • Biomedical Engineering

Background:

  • Accurate assessment of low-frequency hearing thresholds is crucial for diagnosing hearing impairments.
  • Current objective measures may lack precision for low-frequency evaluations.
  • The auditory nerve overlapped waveform (ANOW) response is a novel, non-invasive technique with potential for improved low-frequency hearing assessment.

Purpose of the Study:

  • To investigate the robustness and characteristics of the ANOW response in humans.
  • To establish normative data for ANOW response measures.
  • To evaluate the test-retest reliability of the ANOW response.

Main Methods:

  • Non-invasive recordings of ANOW response in 13 normal-hearing adults (25-40 years).
  • Utilized low-frequency Tone Bursts (TBs) at 250 Hz and 500 Hz at various stimulus levels.
  • Analyzed ANOW absolute amplitude and phase locking value (PLV) for reliability and normative data.

Main Results:

  • ANOW response was successfully recorded down to 30-40 dB nHL for both 250 Hz and 500 Hz TBs.
  • Significantly higher amplitude and stronger phase locking were observed with 250 Hz TBs compared to 500 Hz TBs.
  • High test-retest reliability was achieved for the ANOW response using 250 Hz TBs at presentation levels above 40 dB nHL.

Conclusions:

  • The ANOW response is a viable, non-invasive objective measure for evaluating low-frequency hearing.
  • The robustness of the ANOW response increases as stimulus frequency decreases.
  • This technique shows promise for more accurate assessment of low-frequency hearing thresholds.