Association Between Prediabetes and Osteoarthritis: A Meta-Analysis
Xi Li1, Yong Zhou1, Jianxiu Liu1
1Department of Traumatology Orthopedics, The People's Hospital of Longhua District of Shenzhen, Shenzhen, China.
Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme
|February 7, 2022
Summary
Prediabetes, a precursor to diabetes, is not independently linked to osteoarthritis. This meta-analysis of observational studies found no significant association between prediabetes and the development of osteoarthritis in adults.
Area of Science:
- Metabolic Health and Musculoskeletal Disorders
- Epidemiology and Public Health
Background:
- Diabetes mellitus is a known risk factor for osteoarthritis.
- The association between prediabetes and osteoarthritis remains unclear.
- Prediabetes affects a significant portion of the adult population.
Purpose of the Study:
- To conduct a meta-analysis evaluating the relationship between prediabetes and osteoarthritis.
- To synthesize evidence from observational studies on prediabetes and osteoarthritis risk.
Main Methods:
- Meta-analysis of observational studies sourced from Medline, Embase, and Web of Science.
- Utilized a random-effect model to pool results, accounting for intra-study heterogeneity.
- Included ten datasets from six studies involving over 41,000 adults.
Main Results:
- Pooled analysis revealed no independent association between prediabetes and osteoarthritis (RR: 1.07, 95% CI: 1.00-1.14).
- Sensitivity analyses adjusting for age and BMI yielded consistent results.
- Subgroup analyses showed no association across different study designs, populations, or definitions of prediabetes.
Conclusions:
- Current evidence does not support an independent link between prediabetes and osteoarthritis in adults.
- Further research may be warranted to explore potential indirect relationships or specific subgroups.
- Findings contribute to understanding metabolic influences on joint health.
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