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Updated: Oct 4, 2025
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Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
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Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD.
Mathias Hohl1, Simina-Ramona Selejan1, Jan Wintrich1
1Department of Internal Medicine III, Saarland University Hospital and Saarland University, Homburg/Saar, Germany (M.H., S.-R.S., J.W., U.L., C.S., M. Mauz, P.M., A.K., C.U., C.W., D.L., F.M., M.B.).
Circulation Research
|February 8, 2022
Summary
Renal denervation (RDN) may reduce atrial fibrillation (AF) risk in chronic kidney disease (CKD) by improving atrial remodeling and reducing AF susceptibility. This approach shows promise independent of blood pressure and kidney function changes.
Area of Science:
- Cardiology
- Nephrology
- Medical Research
Background:
- Atrial fibrillation (AF) is common in chronic kidney disease (CKD) and increases stroke and death risk.
- CKD promotes atrial changes and sympathetic nervous system activation, potentially increasing AF vulnerability.
- The effect of renal denervation (RDN) on AF in CKD remains unknown.
Purpose of the Study:
- To investigate if RDN can inhibit AF vulnerability in a CKD model.
- To analyze left atrial (LA) fibrosis and sympathetic innervation in patients and rats with CKD and AF.
Main Methods:
- Human samples with AF and CKD were analyzed for LA fibrosis.
- A rat model of CKD was established using adenine-containing chow.
- RDN or sham operation was performed in CKD rats; cardiac function, AF susceptibility, and LA tissue were assessed.
Main Results:
- Patients with AF and CKD showed increased LA fibrosis compared to those without CKD.
- CKD rats exhibited LA structural changes, enhanced sympathetic innervation, and increased AF susceptibility.
- RDN improved LA remodeling, reduced AF susceptibility, and ameliorated conduction abnormalities in CKD rats, independent of blood pressure and renal function.
Conclusions:
- RDN inhibited atrial remodeling and reduced AF susceptibility in an experimental CKD model.
- RDN is a potential therapeutic strategy to mitigate AF risk in CKD patients.
- The benefits of RDN appear independent of changes in renal function and blood pressure.
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