[Potential regulatory role of long non-coding RNA-microRNA-mRNA axis in sepsis]

Area of Science:

• Molecular Biology
• Immunology
• Critical Care Medicine

Background:

• Sepsis is a life-threatening condition causing multiple organ dysfunction and high mortality, particularly in intensive care units.
• Long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) are implicated in sepsis pathophysiology, regulating inflammatory responses.
• lncRNAs and miRNAs show potential as diagnostic markers and therapeutic targets for sepsis.

Purpose of the Study:

• To review the regulatory interactions between lncRNAs, miRNAs, and messenger RNAs (mRNAs) in sepsis.
• To elucidate the role of the lncRNA-miRNA-mRNA axis in the inflammatory and immune responses during sepsis.
• To explore the axis's involvement in sepsis-induced multiple organ dysfunction syndrome (MODS).

Main Methods:

• Literature review focusing on lncRNA, miRNA, and mRNA interactions in sepsis.
• Analysis of studies detailing the lncRNA-miRNA-mRNA regulatory network.
• Synthesis of findings on the axis's role in inflammatory and immune responses.

Main Results:

• lncRNAs, miRNAs, and mRNAs form complex regulatory networks crucial to sepsis.
• The lncRNA-miRNA-mRNA axis significantly influences inflammatory immune responses in sepsis.
• Dysregulation of this axis contributes to the development of multiple organ dysfunction in sepsis.

Conclusions:

• The lncRNA-miRNA-mRNA axis is a key player in sepsis pathogenesis and progression.
• Targeting the lncRNA-miRNA-mRNA axis presents novel therapeutic strategies for sepsis and associated organ dysfunction.
• Further research into these molecular interactions can lead to improved sepsis management.