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Related Experiment Video

Updated: Oct 4, 2025

Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation

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Published on: August 1, 2010

Posterior Embryotoxon Revisited: An Immunohistologic Study.

Saeed Alwadani¹, Wallace L M Alward², Nasreen A Syed³

¹King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia; Department of Ophthalmology, King Saud University School of Medicine, Riyadh, Saudi Arabia.

Ophthalmology. Glaucoma

|February 8, 2022

Summary

Posterior embryotoxon (PE) is a peripheral corneal stromal nub, not a displaced Schwalbe line. Histopathology reveals variable locations and an abnormal extracellular matrix, challenging current definitions.

Keywords:

Cornea Glaucoma Histology Immunohistochemistry Pathology Posterior embryotoxon

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Area of Science:

Ophthalmology
Histopathology
Corneal Anatomy

Background:

Posterior embryotoxon (PE) is often misidentified as an anteriorly displaced Schwalbe line.
Understanding the true nature of PE is crucial for accurate diagnosis and management.

Purpose of the Study:

To elucidate the immunopathologic features of posterior embryotoxon (PE).
To determine the precise anatomical location and extracellular matrix composition of PE.

Main Methods:

Analysis of archived formalin-fixed, paraffin-embedded corneal specimens from 9 patients with PE.
Light microscopy and immunohistochemistry to characterize the extracellular matrix of PE.

Main Results:

PE presents as peripheral corneal stromal nubs, not a displaced Schwalbe line.
Locations of PE were variable, including anterior to, posterior to, or at Schwalbe line.
Immunohistochemistry showed PE's extracellular matrix is similar to corneal stroma but with some staining variations.

Conclusions:

Histologic findings redefine PE as a corneal stromal extension, not a displaced Schwalbe line.
PE's variable location can displace Descemet membrane.
The extracellular matrix of PE shares similarities with corneal stroma, with distinct staining patterns.