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Updated: Oct 4, 2025
Synthesis of Near-Infrared Emitting Gold Nanoclusters for Biological Applications
Published on: March 22, 2020
Research update of emergent gold nanoclusters: A reinforced approach towards evolution, synthesis mechanism and
Imran Mahmood Khan1, Sobia Niazi1, Lin Yue2
1State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, China; School of Food Science and Technology, Jiangnan University, Wuxi, China; National Engineering Research Centre of Functional Food, Jiangnan University, Wuxi, China.
Abstract:
Fluorescent biosensors and imaging devices have gained fervent consideration due to their prime functionality in biological. Among fluorescent nanomaterial (FNMs), the ultra-small gold nanoclusters (AuNCs) have gained promising attention with respect to extra-ordinary properties of bright fluorescence, economical synthesis, higher photostability, and biocompatibility, and deep tissue penetration. Therefore, the prior decades comprehended the revolutions in the field of real-time monitoring devices, nanotechnology-based biosensing, and bioimaging sensors. The present review primarily focuses on metal NCs (MNCs) and their advantages, a brief introduction of AuNCs along with history prospective and development, fundamental aspects regarding AuNCs quality and fluorescence, limitations and advantages of AuNCs, sensing mechanism, expected synthesis principle, and summarized the recent progress of AuNCs probe over the last 3 years (2019-2021) with their respective detection and bioimaging mechanism and synthesis principle. Moreover, the present work also serves as a novel stratagem for the preparation and potential applications of multifunctional AuNCs nano-systems responsiveness for various analytes detection and cell bioimaging with respective examples. At last, we described the challenges associated with the application of AuNCs based on recent signs of progress.
