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Related Concept Videos

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin01:26

Directly Acting Muscle Relaxants: Dantrolene and Botulinum Toxin

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Directly acting muscle relaxants like dantrolene and botulinum toxin (BoNT) have distinct mechanisms and applications. Dantrolene, a hydantoin derivative, acts on the ryanodine receptor (RYR1) in skeletal muscle cells. RYR1 are calcium channels present at the sarcoplasmic reticulum membrane. In response to excitation, they release calcium ions from the sarcoplasmic reticulum to the cytosol. Calcium promotes actin-myosin-mediated contraction of muscles.
The binding of dantrolene to the RYR1...
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Botulinum toxin combined with rehabilitation decrease corticomuscular coherence in stroke patients.

Célia Delcamp1, Camille Cormier2, Alexandre Chalard3

  • 1ToNIC, Université de Toulouse, Inserm, UPS, Toulouse, France.

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
|February 8, 2022
PubMed
Summary
This summary is machine-generated.

Botulinum toxin and rehabilitation improved brain-muscle connectivity in stroke patients, reducing abnormal muscle co-contraction and enhancing active range of motion. This suggests effective functional reorganization of the central-peripheral network after treatment.

Keywords:
Brain injuriesBrain-muscle connectivityElectroencephalographyElectromyographyNeuromuscular plasticity

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Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Motor Control

Background:

  • Stroke often leads to impaired motor function, characterized by limited active range of motion and increased antagonist co-contraction.
  • Altered brain-muscle connectivity, specifically corticomuscular coherence, is a key indicator of motor control deficits post-stroke.
  • Understanding these alterations is crucial for developing effective rehabilitation strategies.

Purpose of the Study:

  • To investigate the impact of botulinum toxin combined with rehabilitation on corticomuscular coherence in chronic stroke patients.
  • To explore the relationship between changes in corticomuscular coherence, antagonist co-contraction, and active range of motion.
  • To elucidate the functional reorganization of the central-peripheral network following this combined therapeutic approach.

Main Methods:

  • Collected kinematic, electromyographic, and electroencephalographic data during active elbow extensions in chronic stroke patients and healthy controls.
  • Quantified active range of motion, antagonist co-contraction, and corticomuscular coherence.
  • Analyzed changes in these parameters following botulinum toxin injections and rehabilitation interventions.

Main Results:

  • Corticomuscular coherence, initially increased in stroke patients, significantly decreased after botulinum toxin injections and rehabilitation.
  • This reduction in coherence was observed in both agonist and antagonist muscles, with moderate to large effect sizes.
  • Concurrently, a decrease in antagonist co-contraction and an improvement in active range of motion were noted.

Conclusions:

  • This study provides the first evidence that botulinum toxin injections combined with rehabilitation influence corticomuscular coherence in stroke survivors.
  • The findings suggest a treatment-induced functional reorganization of the central-peripheral network.
  • Despite a small sample size, the results offer original insights into neuroplasticity and motor recovery after stroke.