Brugada pattern revealed during SARS-COV-2-related multi-systemic inflammatory syndrome in a 6-year-old child

Area of Science:

• Pediatric Cardiology
• Infectious Diseases
• Pediatric Critical Care Medicine

Background:

• Multisystem inflammatory syndrome in children (MIS-C) is a rare but serious condition associated with COVID-19.
• Cardiac involvement, including rhythm abnormalities, is infrequently reported in MIS-C.
• Brugada pattern is a specific electrocardiographic finding associated with cardiac channelopathies.

Observation:

• A 6-year-old child diagnosed with MIS-C presented with a type I Brugada pattern on electrocardiogram (ECG).
• The child received treatment with systemic steroids and immunoglobulins.
• Serial ECG monitoring revealed a gradual normalization of cardiac rhythm.

Findings:

• The type I Brugada pattern detected in this MIS-C patient is an unusual cardiac manifestation.
• Resolution of the Brugada pattern correlated with clinical improvement and decreasing inflammatory markers.
• This suggests a potential transient electrophysiological disturbance related to the inflammatory process in MIS-C.

Implications:

• This case highlights the importance of comprehensive cardiac evaluation in children with MIS-C, including ECG monitoring.
• Understanding rare cardiac manifestations like Brugada pattern in MIS-C can improve diagnostic accuracy.
• Further research is needed to elucidate the mechanisms linking MIS-C and transient cardiac electrical abnormalities.