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Consequences of anti-vascular endothelial growth factor treatment lapse in patients with retinal vein occlusion

Jessica C Liu1, Peter Alsaloum1, Amogh I Iyer2

  • 1Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH, 44106, USA.

Eye (London, England)
|February 8, 2022
PubMed
Abstract

Insights

Gaps in anti-vascular endothelial growth factor (VEGF) therapy for Retinal Vein Occlusion (RVO) worsen anatomic and visual outcomes. While vision may recover, retinal thickness increases persist, impacting long-term RVO management.

Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Medical Treatments

Background:

  • Anti-vascular endothelial growth factor (VEGF) therapy is a primary treatment for Retinal Vein Occlusion (RVO).
  • Limited data exists on the consequences of treatment interruptions in RVO patients undergoing anti-VEGF therapy.

Purpose of the Study:

  • To investigate the impact of anti-VEGF treatment lapses on the anatomical and visual results in patients with Retinal Vein Occlusion (RVO).

Main Methods:

  • A retrospective case-control study involving 136 RVO patients treated with anti-VEGF.
  • Patients were categorized into two groups: those with no lapse and those with a lapse of ≥3 months.
  • Central subfield thickness (CST) and best-corrected visual acuity (BCVA) were monitored pre- and post-lapse.

Main Results:

  • Patients with treatment lapses showed a significant increase in CST compared to controls, persisting even after treatment resumption.
  • A notable decrease in BCVA was observed in the lapse group, which improved after 6 months of re-treatment.
  • Pre-lapse CST and BCVA were similar between the lapse and control groups.

Conclusions:

  • Lapses in anti-VEGF treatment for RVO are associated with adverse anatomic and visual outcomes.
  • While visual acuity may normalize with treatment resumption, persistent increases in retinal thickness (CST) indicate lasting structural changes.

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