Related Experiment Video
Updated: Oct 4, 2025
03:26
Detrusor Underactivity Model in Rats by Conus Medullaris Transection
Published on: August 28, 2020
2.2K
Overactive bladder medication prescription trends from 2014 to 2018
Abhishek Sripad1, Christina Raker2, Theresa Shireman3
1Division of Urogynecology, Department of Obstetrics & Gynecology, Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Neurourology and Urodynamics
|February 8, 2022
Summary
Overactive bladder (OAB) medication use and spending increased from 2014-2018. Mirabegron claims rose, while immediate-release anticholinergics decreased, warranting further clinical outcome investigation.
Area of Science:
- Gerontology
- Pharmacology
- Public Health
Background:
- Growing evidence suggests a link between overactive bladder (OAB) medications and dementia risk.
- Differences in side effect profiles exist between extended-release (ER) and immediate-release (IR) anticholinergic formulations, as well as beta-3 agonists.
Purpose of the Study:
- To examine prescription utilization patterns of OAB medications in older adults.
- To analyze trends in OAB medication claims and spending from 2014 to 2018.
- To assess changes in anticholinergic burden by medication type and formulation.
Main Methods:
- Retrospective study utilizing the Medicare Part D Drug Spending Dashboard (2014-2018).
- Analysis of outpatient pharmacy claims to identify total claims and spending on common OAB medications.
- Assessment of trends by anticholinergic burden, medication, and immediate-release (IR) versus extended-release (ER) formulations.
Main Results:
- Over 54.1 million claims for OAB medications totaling $10.1 billion were recorded from 2014-2018.
- Mirabegron (a beta-agonist) proportion of claims and spending increased significantly (5.7% to 20.1% and 11.3% to 44%, respectively).
- Immediate-release (IR) anticholinergic claims decreased from 58.5% to 42.6%, while extended-release (ER) formulations showed a slight proportional increase then decrease.
Conclusions:
- OAB medication utilization and expenditures rose between 2014 and 2018.
- Mirabegron use increased, while IR anticholinergic use declined.
- Further investigation into the clinical outcomes associated with these shifting OAB medication trends is crucial.
Related Concept Videos
01:02Prescription, Nonprescription and Orphan Drugs
883
Prescription drugs require a prescription from a medical practitioner and can only be obtained from a pharmacy. They have many applications, including treating pain, anxiety, and hypertension.
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
The misuse and addiction to prescription drugs is a growing problem that can affect people of all age groups, specifically teenagers. This can happen when prescription medications are used in ways not intended by the prescriber, such as taking someone else's prescription or using medication for...
883
01:17Drugs for Treatment of Diarrhea-Predominant IBS
343
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
343
01:30Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
64
A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
64
01:21Drugs for Treatment of Constipation-Predominant IBS
362
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
362
01:23Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
467
Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...
467
01:19Urodynamic Studies: Uroflowmetry
872
Uroflowmetry is a non-invasive urodynamic test designed to measure various aspects of urination, including volume, flow rate, and the time to void. This test is crucial for diagnosing and assessing conditions such as bladder outlet obstruction, bladder dysfunction, incomplete bladder emptying, incontinence, and urinary tract blockages caused by benign prostatic hyperplasia (BPH) and urethral strictures.Pre-Test Instructions:Before a uroflowmetry test, patients are typically advised to drink...
872