The priming effect of glucose on the gastric inhibitory polypeptide-induced insulin release

Six healthy subjects were given a 15-min intravenous infusion of gastric inhibitory polypeptide (GIP) in a dose of 1.0 microgram X kg-1 X h-1 at a mean blood glucose level of 4.9 mmol/l after a priming infusion with glucose. A significant insulin release was seen during the GIP infusion, an effect that could not be demonstrated without the priming glucose infusion.