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Updated: Oct 4, 2025
Combined Near-infrared Fluorescent Imaging and Micro-computed Tomography for Directly Visualizing Cerebral Thromboemboli
Published on: September 25, 2016
Fibrinogen aptamer functionalized gold-coated iron-oxide nanoparticles for targeted imaging of thrombi
Anna Koudrina1, Celine Chartrand1, Greg O Cron2,3,4
1Department of Chemistry, Carleton University, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada. maria.derosa@carleton.ca.
Abstract:
Targeting of molecular constituents of thrombi with aptamer functionalized core-shell nanoparticles (CSN) allowed for high resolution clot delineation in T2-weighted magnetic resonance imaging. Meanwhile, the gold-coating demonstrated sufficient contrast capabilities in computed tomography (1697 HU μM-1). This targeted CSN formulation could allow for precise imaging of blood clots at low nanomolar concentrations.
