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Updated: Oct 4, 2025

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Screening Assay for Oxidative Stress in a Feline Astrocyte Cell Line, G355-5
Published on: July 13, 2011
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Alpha lipoic acid toxicosis in cats (2008-2016): Four cases
Marcia M Carpenter1, Lynn R Hovda1
1Pet Poison Helpline, Bloomington, Minnesota, USA.
Summary
Alpha lipoic acid ingestion in cats can cause vomiting and has a high mortality rate. This case series highlights the severe risks associated with alpha lipoic acid toxicity in felines.
Area of Science:
- Veterinary Toxicology
- Small Animal Medicine
- Feline Health
Background:
- Alpha lipoic acid is a naturally occurring compound used as a dietary supplement.
- Limited data exists on the toxic effects of alpha lipoic acid in cats.
- Understanding feline toxicity is crucial for prompt diagnosis and treatment.
Purpose of the Study:
- To document clinical signs, treatments, and outcomes in cats following alpha lipoic acid ingestion.
- To establish the potential toxicity of alpha lipoic acid in felines.
- To provide a reference for future cases of suspected alpha lipoic acid poisoning.
Main Methods:
- Retrospective review of four feline cases with confirmed alpha lipoic acid ingestion.
- Analysis of clinical signs, diagnostic findings, and treatment protocols.
- Evaluation of patient outcomes, including survival and mortality.
Main Results:
- Vomiting was a consistent clinical sign in all affected cats.
- Two out of the four cases resulted in fatality, indicating a significant mortality rate.
- Other potential clinical signs and treatment responses were noted.
Conclusions:
- This study represents the first reported case series on alpha lipoic acid ingestion in cats.
- Alpha lipoic acid poses a serious toxic risk to felines.
- Veterinarians should be aware of these risks when managing suspected poisonings.
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