Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroleptic malignant syndrome.

M P Rampertaap

    Southern Medical Journal
    |March 1, 1986
    PubMed
    Summary

    Neuroleptic Malignant Syndrome (NMS) is a rare, lethal disorder from neuroleptic drugs, often underdiagnosed. Bromocriptine and supportive care effectively treated three NMS cases, highlighting treatment options.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Depression in a geriatric patient: alleviation by insertion of a pacemaker.

    Southern medical journal·1986
    Same author

    Vitiligo-like syndrome following the use of fluphenazine enanthate.

    Missouri medicine·1985
    See all related articles

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Clinical Medicine

    Background:

    • Neuroleptic Malignant Syndrome (NMS) is a rare, life-threatening condition linked to neuroleptic medications.
    • It is frequently underdiagnosed due to poor recognition and understanding.
    • NMS affects all ages and carries a significant 20% mortality rate.

    Observation:

    • Key symptoms include extrapyramidal signs, altered mental status, autonomic instability, and hyperthermia.
    • Pathophysiology involves dopaminergic system disruption in the basal ganglia and hypothalamus.
    • Existing treatments like dantrolene, amantadine, and bromocriptine show efficacy with supportive care.

    Findings:

    • This report details three cases of NMS successfully managed with bromocriptine and supportive interventions.
    • Bromocriptine demonstrated effectiveness in treating the syndrome.

    Implications:

    • Early recognition and prompt treatment are crucial for improving NMS outcomes.
    • Bromocriptine represents a viable therapeutic option for NMS management.
    • Further research into NMS pathophysiology and treatment is warranted.

    Related Experiment Videos