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Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
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Pattern-based Search of Epigenomic Data Using GeNemo
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Genomic perspectives on epigenetics.

Jung-Shin Lee1, Nam-Soo Kim2,3

  • 1Department of Molecular Bioscience, Kangwon National University, Chuncheon, 24341, South Korea.

Genes & Genomics
|February 8, 2022
PubMed
Summary
This summary is machine-generated.

Genes and environment interact to shape traits, with epigenetics modifying gene expression without altering DNA. This review explores genomic insights into epigenetics, highlighting recent advancements.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • Historically, genes were thought to solely determine phenotypes.
  • Eukaryotic genomes contain abundant noncoding DNA, with a small fraction encoding proteins.
  • The understanding of gene function has evolved beyond simple genetic determinism.

Purpose of the Study:

  • To review recent advancements in genomic perspectives on epigenetics.
  • To highlight the complex interplay between genes, environment, and phenotype.
  • To define epigenetics as stably heritable phenotypes from chromosomal changes without DNA sequence alteration.

Main Methods:

  • Review of 12 articles on genomic perspectives on epigenetics.
  • Synthesis of current understanding in molecular biology and genomics.
  • Analysis of epigenetic regulation mechanisms.

Main Results:

  • Genes do not solely dictate phenotypes; they interact with the environment.
  • Epigenetic regulation plays a crucial role in modifying gene expression.
  • Significant progress has been made in understanding the genomic basis of epigenetics.

Conclusions:

  • Phenotypes result from gene-environment interactions, influenced by epigenetics.
  • Epigenetics provides a mechanism for heritable traits without DNA sequence changes.
  • Genomic insights are crucial for unraveling the complexities of epigenetics.