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Ene-Reductase: A Multifaceted Biocatalyst in Organic Synthesis
Triptesh Kumar Roy1, Ramdas Sreedharan2, Pintu Ghosh3
1Department of Chemistry, Indian Institute of Science Education and Research (IISER) Tirupati, Tirupati, India.
Chemistry (Weinheim an Der Bergstrasse, Germany)
|February 8, 2022
Summary
Ene-reductases (ERs) offer highly selective biocatalysis for chemical synthesis, replacing precious metals. Recent advances expand their use in chemoenzymatic and novel photoelectrochemical/radical processes.
Area of Science:
- Biocatalysis and Organic Chemistry
- Enzyme Engineering and Applications
Background:
- Biocatalysis provides high selectivity (chemo-, regio-, enantioselectivity) for pharmaceuticals and agrochemicals.
- Ene-reductases (ERs), from the Old Yellow Enzymes (OYEs) family, are key biocatalysts for asymmetric hydrogenation of activated C=C bonds.
- ERs offer an alternative to traditional methods using precious metals and chiral ligands.
Purpose of the Study:
- To review recent advancements in organic transformations utilizing Ene-reductases (ERs).
- To highlight the expanding applications of ERs in academia and industry.
- To explore novel methodologies involving ERs beyond traditional biocatalysis.
Main Methods:
- Literature review of studies published in the last five years.
- Analysis of ERs' application as individual catalysts, in multi-enzyme cascades, and chemoenzymatic approaches.
- Investigation of ERs' role in photoelectrochemical and radical-mediated reactions.
Main Results:
- ERs demonstrate significant potential in stereoselective trans-hydrogenations.
- ERs are increasingly integrated into complex catalytic systems and chemoenzymatic strategies.
- Emerging applications showcase ERs in photo- and electrocatalysis, and radical chemistry.
Conclusions:
- Ene-reductases are versatile biocatalysts with growing importance in sustainable chemical synthesis.
- Continued exploration of ERs promises to unlock new industrial applications and expand biocatalytic methodologies.
- ERs are pivotal in developing greener and more efficient synthetic routes for valuable chemicals.
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