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Managing Metastatic Melanoma in 2022: A Clinical Review

Benjamin Switzer1, Igor Puzanov1, Joseph J Skitzki2

  • 1Department of Medicine, Roswell Park Comprehensive Cancer Center, Buffalo, NY.

JCO Oncology Practice
|February 8, 2022
PubMed

Insights

Advances in immunotherapy and targeted treatments have improved outcomes for metastatic melanoma patients. This review details current and future strategies for managing advanced melanoma, including risk stratification and toxicity management.

Area of Science:

  • Oncology
  • Dermatology
  • Immunology

Background:

  • Cutaneous melanoma is a lethal skin cancer with rising incidence.
  • Metastatic melanoma mortality remains a significant challenge despite treatment advances.
  • Recent progress in immunomodulatory and targeted therapies has transformed patient care.

Purpose of the Study:

  • To provide a comprehensive overview of historical and future advances in advanced melanoma.
  • To discuss the translational and clinical implications of these developments.
  • To offer multidisciplinary recommendations for clinicians managing advanced melanoma patients.

Main Methods:

  • Literature review of recent advancements in melanoma research and treatment.
  • Analysis of immunologic and cancer cell biology contributions.
  • Synthesis of multidisciplinary recommendations for clinical practice.

Main Results:

  • Immunomodulatory and targeted therapies have significantly improved response and survival rates.
  • Advances optimize risk stratification, prognostication, treatment, toxicity management, and surveillance.
  • New insights enhance the clinical management of advanced melanoma.

Conclusions:

  • Current treatment paradigms for advanced melanoma have been revolutionized by immunotherapy and targeted therapies.
  • Multidisciplinary approaches are crucial for effective patient management.
  • Future research directions are essential for continued progress in combating metastatic melanoma.

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