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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
Published on: April 20, 2018
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A Systematic Review of Head and Neck Cancer Health Disparities: A Call for Innovative Research
Rohit Nallani1, Thamara L Subramanian2, Kiatana M Ferguson-Square3
1Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, Kansas, USA.
Summary
This review of head and neck cancer disparities found most research focuses on individual factors. Future studies should examine community and societal influences to promote health equity.
Area of Science:
- Health Services Research
- Cancer Disparities
- Public Health
Background:
- Extensive research exists on head and neck cancer health disparities.
- Studies predominantly focus on individual patient factors and healthcare system influences.
Purpose of the Study:
- To describe existing head and neck cancer health disparities literature.
- To contextualize studies using the National Institute on Minority Health and Health Disparities (NIMHD) research framework.
- To explore innovative research and intervention strategies.
Main Methods:
- Systematic literature search of Ovid MEDLINE, Embase, Web of Science, and Google Scholar (inception to April 2020).
- Included 148 articles, classifying them per the NIMHD research framework.
- Followed PRISMA checklist with two independent reviewers.
Main Results:
- Majority of studies (n=104) focused on race/ethnicity-related disparities.
- Over two-thirds (n=105) identified disparities in health behaviors or clinical outcomes.
- Most discussed interactions between individual and health system domains (n=99).
Conclusions:
- Current research on head and neck cancer disparities is extensive but lacks depth on contributing factors.
- A shift towards community and societal factors is recommended over individual-focused research.
- Further evaluation of interventions is needed to advance health equity.
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