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Field Effect Transistor

Field Effect Transistor

Field-effect transistors (FETs) are integral to electronic circuits and distinguished by their three-terminal setup: the gate, drain, and source. These transistors operate as unipolar devices, which utilize either electrons or holes as charge carriers, in contrast to bipolar transistors, which use both types of carriers. The primary function of the FET is to modulate the flow of these carriers from the source to the drain through a channel. The voltage difference between the gate and source...

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Field-Effect Transistor with a Plasmonic Fiber Optic Gate Electrode as a Multivariable Biosensor Device.

Roger Hasler¹, Ciril Reiner-Rozman², Stefan Fossati¹

¹AIT Austrian Institute of Technology GmbH, Konrad-Lorenz-Strasse 24, 3430 Tulln, Austria.

|February 8, 2022

Summary

This study introduces a novel dual-mode sensor combining transistor technology and fiber optic surface plasmon resonance spectroscopy. This innovative biosensor enables simultaneous mass and charge detection for enhanced binding assays.

Keywords:

electrolyte-gated field-effect transistor (EG-FET)fiber optics layer-by-layer (LBL) assemblies multivariant sensing sensor geometry surface investigation surface plasmon resonance (SPR)

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Area of Science:

Nanotechnology
Spectroscopy
Biosensing

Background:

Surface plasmon resonance (SPR) is a powerful label-free optical sensing technique.
Integrating SPR with transistor technology offers potential for enhanced sensitivity and multiplexed detection.
Current SPR systems often lack the ability to differentiate between mass and charge binding events.

Purpose of the Study:

To develop and characterize a novel multivariable sensor system combining transistor and fiber optic SPR.
To enable simultaneous discrimination of mass and charge contributions in binding assays.
To optimize sensor geometry for improved electronic and optical signal transduction.

Main Methods:

Fabrication of a hybrid transistor-fiber optic SPR sensor where the gate electrode serves as the sensor surface.
Systematic investigation of sensor geometry parameters, including fiber area to transistor channel area ratio and distance.
Demonstration of dual-mode sensing capabilities and reversibility of optical signals via electric field application.
Validation using layer-by-layer polyelectrolyte assembly and a thrombin binding assay with aptamer receptors.

Main Results:

Successful integration of transistor and fiber optic SPR functionalities into a single sensor platform.
Optimization of sensor geometry leading to improved electronic and optical signal detection.
Demonstrated ability to discriminate between mass and charge binding events on the same sensor.
Achieved reversible plasmon resonance wavelength shifts upon electric field application.
Successful detection of medically relevant thrombin concentrations in a biosensing assay.

Conclusions:

The developed dual-mode sensor offers a novel approach for multivariable analysis in biosensing.
This platform provides simultaneous discrimination of mass and charge binding, enhancing assay capabilities.
The optimized sensor geometry and demonstrated reversibility pave the way for advanced biosensing applications.