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Related Experiment Video

Updated: Oct 4, 2025

Evaluation of the Cognitive Performance of Hypertensive Patients with Silent Cerebrovascular Lesions
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Basal ganglia calcifications: No association with cognitive function.

Esther Jm de Brouwer1, Nienke Ms Golüke1, Jules J Claus2

  • 1University Medical Center Utrecht, Utrecht University, Department of Geriatrics, Utrecht, the Netherlands; Tergooi Medical Center, Department of Geriatrics, Blaricum, the Netherlands.

Journal of Neuroradiology = Journal De Neuroradiologie
|February 8, 2022
PubMed
Summary
This summary is machine-generated.

Basal ganglia calcifications (BGC) were not linked to cognitive decline in patients. Female gender was a risk factor for BGC, while hypertension and its treatment showed a protective effect.

Keywords:
Basal gangliaCalcificationCardiovascularCognitionComputed tomography

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Area of Science:

  • Neurology
  • Radiology
  • Geriatrics

Background:

  • Basal ganglia calcifications (BGC) are common findings on brain CT scans.
  • BGC represent a form of vascular calcification within the brain.

Purpose of the Study:

  • To investigate the association between BGC and cognitive function.
  • To examine the relationship between vascular risk factors and the presence of BGC.

Main Methods:

  • A cohort of 1992 patients from a memory clinic underwent cognitive testing and brain CT.
  • Vascular risk factors including hypertension, diabetes, hyperlipidemia, and smoking were assessed.
  • Multivariable logistic and linear regression analyses were employed to identify risk factors and cognitive associations.

Main Results:

  • 43.5% of patients exhibited BGC.
  • BGC were associated with female gender (OR 1.27) but inversely with hypertension (OR 0.74) and antihypertensive drug use (OR 0.79).
  • No significant association was found between BGC presence/severity and cognitive function or other vascular risk factors.

Conclusions:

  • BGC were not associated with cognitive function in this patient cohort.
  • Female gender emerged as a risk factor for BGC.
  • Hypertension and antihypertensive medication use were associated with a reduced risk of BGC.