The interaction between ethanol and antihistamines. 1: Dexchlorpheniramine

Area of Science:

• Pharmacology
• Neuroscience
• Human Physiology

Background:

• Dexchlorpheniramine is an antihistamine with potential sedative effects.
• Ethanol (alcohol) is a central nervous system depressant.
• Interactions between medications and alcohol can impact cognitive and motor functions.

Purpose of the Study:

• To investigate the combined effects of dexchlorpheniramine and ethanol on human functions.
• To assess potential synergistic or antagonistic interactions between the two substances.
• To evaluate the duration of impairment following combined administration.

Main Methods:

• Double-blind, placebo-controlled crossover study design.
• Thirteen healthy student volunteers participated.
• Oral administration of dexchlorpheniramine (4 mg/70 kg) and ethanol (0.75 g/kg) individually and in combination.

Main Results:

• A synergistic effect of dexchlorpheniramine and ethanol was observed in some tests.
• Delayed recovery from the combined effects was noted.
• Subjective reports indicated enhanced sedative effects of dexchlorpheniramine when combined with ethanol.

Conclusions:

• Concurrent use of dexchlorpheniramine and ethanol may lead to prolonged impairment of perceptual, cognitive, and motor functions.
• The combination appears to potentiate the sedative effects of dexchlorpheniramine.
• Caution is advised regarding the simultaneous intake of this antihistamine and alcohol.