Elevated mid-trimester 4-h postprandial triglycerides for predicting late-onset preeclampsia: a prospective screening...

Area of Science:

• Obstetrics and Gynecology
• Metabolic Disorders
• Cardiovascular Health in Pregnancy

Background:

• Abnormal maternal lipid profiles are linked to preeclampsia.
• Limited research exists on postprandial triglyceride levels in early pregnancy and preeclampsia risk.

Purpose of the Study:

• To assess the predictive value of triglyceride (TG) levels during an oral lipid tolerance test (OLTT) in the second trimester for preeclampsia.
• To explore lipid metabolic alterations associated with preeclampsia.

Main Methods:

• Prospective cohort study involving pregnant women (12-24 weeks gestation) undergoing an OLTT.
• Receiver operating characteristic (ROC) curve analysis to identify optimal cut-off points for predicting preeclampsia.
• Stratification of data based on OLTT results.

Main Results:

• Women who developed preeclampsia had significantly higher 4-hour postprandial TG concentrations.
• Mid-trimester 4-hour postprandial TG levels were a significant predictor of preeclampsia in logistic regression analyses.
• 438 pregnant women were recruited; 24 developed preeclampsia.

Conclusions:

• Second-trimester dyslipidemia, especially postprandial hypertriglyceridemia, is associated with increased preeclampsia risk.
• Mid-trimester 4-hour postprandial TG concentration from OLTT may serve as a potential biomarker for preeclampsia prediction.