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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Clopidogrel-induced Eosinophilia with Hypercalcemia.

Kazuhiro Yamada1, Kazuhisa Asai1, Misaki Yanagimoto1

  • 1Department of Respiratory Medicine, Osaka Metropolitan University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|February 9, 2022
PubMed
Summary

A rare case of drug-induced eosinophilia with hypercalcemia was reported. Discontinuing clopidogrel resolved the patient's eosinophilia and hypercalcemia, highlighting the importance of detailed medical history.

Keywords:
clopidogreldrug-induced eosinophiliaeosinophiliahypercalcemia

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Area of Science:

  • Internal Medicine
  • Pharmacology
  • Pulmonology

Background:

  • Eosinophilia and hypercalcemia are rarely associated conditions.
  • Drug-induced eosinophilia leading to hypercalcemia has not been previously reported.
  • Asthma diagnosis in a 74-year-old male.

Observation:

  • Patient presented with concurrent eosinophilia and hypercalcemia.
  • Chest CT revealed a left lung nodule and mediastinal lymphadenopathy.
  • Clopidogrel was identified as a potential causative agent through detailed history.

Findings:

  • Discontinuation of clopidogrel led to the resolution of eosinophilia and hypercalcemia.
  • Associated lung nodule and mediastinal lymphadenopathy also improved.
  • This case suggests clopidogrel-induced eosinophilia can manifest with hypercalcemia.

Implications:

  • Detailed patient history is crucial for diagnosing eosinophilia causes.
  • Clopidogrel should be considered in cases of unexplained eosinophilia and hypercalcemia.
  • This finding expands the known adverse effects of clopidogrel.