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Inappropriate prescribing: hazards and solutions.

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Summary
This summary is machine-generated.

Older adults face increased risks of drug-related problems (DRPs) and inappropriate prescribing (IP) due to multimorbidity and polypharmacy. Comprehensive geriatric assessment is crucial for optimizing pharmacotherapy in this population.

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Area of Science:

  • Geriatrics
  • Pharmacology
  • Internal Medicine

Background:

  • Population aging leads to increased multimorbidity and polypharmacy in older adults.
  • Polypharmacy is associated with a higher incidence of drug-related problems (DRPs) and potentially inappropriate prescribing (IP).

Purpose of the Study:

  • To discuss the susceptibility of older adults to DRPs and IP.
  • To elaborate on strategies for identifying DRPs and optimizing IP in older patients.
  • To highlight the importance of comprehensive geriatric assessment for informed prescribing decisions.

Main Methods:

  • Review and discussion of factors contributing to DRPs and IP in older adults.
  • Elaboration on methods for identifying and preventing IP, including drug reconciliation and computer-based systems.
  • Emphasis on comprehensive geriatric assessment and management.

Main Results:

  • Older adults are susceptible to DRPs due to physiological changes, multiple prescribers, and polypharmacy consequences like prescribing cascades and drug interactions.
  • Comprehensive geriatric assessment aids in balancing pharmacotherapy benefits against risks in multimorbid older patients.
  • Integrating clinical information into a wide-reaching approach is a challenge for future research.

Conclusions:

  • Good prescribing in late life requires accommodating the needs of older patients with multimorbidity.
  • An individualized, interactive, multidisciplinary, and multifaceted approach to geriatric pharmacotherapy is recommended.
  • Optimizing pharmacological prescriptions for complex older patients is a key legacy of geriatrics.