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Oogenesis

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...

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Related Experiment Video

Updated: Oct 4, 2025

Human Egg Maturity Assessment and Its Clinical Application

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

Non-invasive oocyte quality assessment.

Romualdo Sciorio¹, Daniel Miranian², Gary D Smith^2,3

¹Edinburgh Assisted Conception Programme, EFREC, Royal Infirmary of Edinburgh, Edinburgh, UK.

Biology of Reproduction

|February 9, 2022

Summary

Assessing human oocyte quality is crucial for female fertility. Future research needs advanced non-invasive techniques, integrating multiple technologies for better prediction of pregnancy success.

Keywords:

chromatin content cumulus cells follicle non-invasive assessment oocyte oocyte maturation

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Human Egg Maturity Assessment and Its Clinical Application

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Published on: September 13, 2022

Area of Science:

Reproductive biology
Biomedical engineering
Genomics

Background:

Oocyte quality is a key factor in female fertility, but current assessment methods have limited predictive power for pregnancy success.
Developing reliable non-invasive techniques for oocyte competence evaluation is essential.

Purpose of the Study:

To review the predictive value of non-invasive techniques for assessing human oocyte developmental competence.
To explore emerging technologies and their potential role in oocyte assessment.

Main Methods:

Review of current research on proteomic, transcriptomic, and hormonal analysis of follicular fluid and cumulus-oocyte complexes.
Discussion of polar body morphology, zygotic viscoelasticity, and metabolic profiling.
Exploration of novel imaging techniques like polarized light and Raman microspectroscopy.

Main Results:

Current non-invasive methods show limited predictive value; further prospective trials are needed.
The roles of polar body morphology and genetics remain debated.
Novel imaging and metabolomic techniques show promise but require further development and integration.

Conclusions:

Advanced non-invasive assessment of oocytes requires integrating diverse technologies such as chemistry, genomics, microfluidics, and microscopy.
Future research should focus on developing and validating these integrated approaches for improved oocyte evaluation and prediction of fertility outcomes.