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Comparison of desmopressin and enuresis alarm for nocturnal enuresis

S Wille

    Archives of Disease in Childhood
    |January 1, 1986
    PubMed

    Insights

    The enuresis alarm showed a higher improvement rate for nocturnal enuresis than desmopressin (DDAVP). However, desmopressin offers a rapid effect and is a useful alternative when conditioning treatment fails.

    Area of Science:

    • Pediatric Nephrology
    • Urology
    • Sleep Medicine

    Background:

    • Primary nocturnal enuresis affects a significant number of children.
    • Current treatments include behavioral interventions like enuresis alarms and pharmacotherapy such as desmopressin (DDAVP).

    Purpose of the Study:

    • To compare the efficacy and safety of desmopressin (DDAVP) versus enuresis alarm in treating primary nocturnal enuresis.
    • To evaluate long-term treatment effectiveness and relapse rates.

    Main Methods:

    • Randomized controlled trial involving 50 children with primary nocturnal enuresis.
    • Participants were treated with either 20 micrograms intranasal desmopressin or an enuresis alarm for three months.
    • Cross-over design for treatment failures and continued treatment for relapses over an additional three months.

    Main Results:

    • Improvement rates were 70% for desmopressin and 86% for the enuresis alarm, with no statistically significant difference.
    • Desmopressin group showed significantly drier nights during the first week of treatment.
    • Higher relapse rate observed in the desmopressin group (10 patients) compared to the alarm group (1 patient).

    Conclusions:

    • Enuresis alarm (conditioning treatment) is preferable for long-term management of nocturnal enuresis.
    • Desmopressin (DDAVP) is a valuable alternative for rapid effect or when conditioning treatment is unsuccessful.
    • No serious adverse effects were reported for either treatment modality.

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