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Microbial Biosensors01:17

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Microbial biosensors are analytical devices that utilize living microbes to detect specific substances through measurable signals. These devices consist of two main components: biosensing organisms and signal-transducing elements. Biosensing organisms, such as Escherichia coli or Saccharomyces cerevisiae, are typically housed in multiwell plates connected to transducers, enabling rapid, real-time detection of target analytes.Signal Generation MechanismWhen a target analyte—such as...

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Lensless Fluorescent Microscopy on a Chip
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SE-ECL on CMOS: a miniaturized electrochemiluminescence biosensor.

Reza Abbasi1, Juanjuan Liu1, Sorina Suarasan2

  • 1Department of Bioengineering, McGill University, Montreal, QC, Canada. sebastian.wachsmannhogiu@mcgill.ca.

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This study presents a novel electrochemiluminescence (ECL) biosensor integrated onto a CMOS chip for point-of-need analysis. The device simplifies sample handling and data collection for detecting biomarkers like uric acid (UA).

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Area of Science:

  • Biosensing technologies
  • Microfluidics
  • Complementary metal-oxide-semiconductor (CMOS) integrated circuits

Background:

  • Biosensors offer point-of-need analyte detection.
  • Electroluminescence (ECL) biosensors combined with microfluidics enable lab-on-a-chip devices.
  • Conventional ECL data recording requires complex instrumentation.

Purpose of the Study:

  • To develop an integrated microfluidic and ECL biosensor on a CMOS chip.
  • To simplify sample handling and data collection on a single platform.
  • To demonstrate the platform's utility for detecting uric acid (UA).

Main Methods:

  • Integration of luminol/hydrogen peroxide ECL system with microfluidics on a CMOS chip.
  • Utilization of a single electrode as an electrochemical transducer.
  • On-chip data collection using the CMOS chip as a built-in detector.

Main Results:

  • Demonstrated UA detection with a linear range of 25–300 μM and a limit of detection (LOD) of 26.09 μM.
  • Achieved high reusability, reproducibility, and selectivity for UA.
  • Validated performance in simulated saliva and urine samples.
  • Exhibited an eightfold increase in photon collection efficiency compared to other ECL imaging platforms.

Conclusions:

  • The developed platform offers an inexpensive, portable, and efficient solution for point-of-need analyte measurement.
  • The integrated CMOS-based ECL biosensor shows significant potential for medical diagnostics.
  • This approach overcomes limitations of conventional ECL data acquisition systems.