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Tumor necrosis factor‑α in systemic lupus erythematosus: Structure, function and therapeutic implications (Review)

Farid Ghorbaninezhad1, Patrizia Leone2, Hajar Alemohammad3

  • 1Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, East Azerbaijan 5165665811, Iran.

International Journal of Molecular Medicine
|February 9, 2022
PubMed
Summary

Tumor necrosis factor-alpha (TNF-α) plays a dual role in systemic lupus erythematosus (SLE) pathogenesis, acting as both an immune regulator and a pro-inflammatory mediator. Anti-TNF-α therapies show potential efficacy and safety in SLE treatment.

Keywords:
autoimmune diseasesystemic lupus erythematosustumor necrosis factor receptortumor necrosis factor‑α

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