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Related Concept Videos

Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Preparation of DNA-crosslinked Polyacrylamide Hydrogels
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Recent Advances in Stimuli-Responsive DNA-Based Hydrogels.

Chen Wang1, Junji Zhang2

  • 1School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, China.

ACS Applied Bio Materials
|February 9, 2022
PubMed
Summary
This summary is machine-generated.

Stimuli-responsive DNA hydrogels offer tunable properties for intelligent materials. This review covers advances in DNA hydrogels for diverse applications like biosensing and drug delivery.

Keywords:
DNA nanotechnologyDNA−polymer hybrid hydrogelsadaptive functionspure DNA hydrogelsstimuli responsiveness

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Synthetic Biology

Background:

  • DNA-based hydrogels are gaining attention due to their responsiveness, biocompatibility, and design flexibility.
  • Integrating reconfigurable DNA architectures and switchable cross-linkers allows for external stimuli-responsive hydrogel property tuning.
  • These intelligent DNA-based materials are crucial for advanced applications.

Purpose of the Study:

  • To review recent advancements in stimuli-responsive DNA hydrogels.
  • To highlight the design of pure DNA, DNA-polymer hybrid, and autonomous DNA hydrogels.
  • To summarize applications and identify future challenges and prospects.

Main Methods:

  • Review of literature on chemically and physically triggered DNA-based hydrogels.
  • Analysis of design strategies for responsive hydrogels.
  • Summarization of applications in various fields.

Main Results:

  • Recent progress in pure DNA, DNA-polymer hybrid, and autonomous DNA hydrogels is presented.
  • Diverse applications including biosensing, biocatalysis, drug delivery, and robotic actuators are detailed.
  • The review covers both chemically and physically triggered systems.

Conclusions:

  • Stimuli-responsive DNA hydrogels represent a promising class of intelligent materials.
  • Their tunable properties and versatile applications underscore their potential in advanced technologies.
  • Addressing key challenges will pave the way for future innovations in this field.