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Updated: Oct 4, 2025
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A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
Published on: November 6, 2015
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Study protocol: Prosthesis versus Active (ProAct) exercise program in patients with glenohumeral osteoarthritis - a
Josefine Beck Larsen1, Theis Muncholm Thillemann2, Antti P Launonen3
1Department of Orthopaedic Surgery, Aarhus University Hospital, Aarhus N, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus N, Denmark . josefinebl@clin.au.dk.
Acta Orthopaedica
|February 9, 2022
Summary
Total shoulder arthroplasty (TSA) offers an alternative to exercise for glenohumeral osteoarthritis. This trial compares TSA with a 12-week exercise program to determine superior outcomes for shoulder pain and function.
Area of Science:
- Orthopedics
- Rheumatology
- Clinical Trials
Background:
- Glenohumeral osteoarthritis (OA) causes pain and functional limitations.
- Total shoulder arthroplasty (TSA) and structured exercise programs are established treatments for OA.
- Direct comparative data from randomized controlled trials (RCTs) between TSA and non-surgical options for glenohumeral OA are limited.
Purpose of the Study:
- To compare the effectiveness of TSA followed by standard rehabilitation versus a 12-week exercise program in patients with glenohumeral OA.
- To evaluate which treatment yields superior patient-reported quality of life and functional outcomes.
Main Methods:
- A Nordic multicenter randomized controlled clinical trial.
- 102 patients with glenohumeral OA eligible for unilateral TSA will be randomized.
- Intervention groups: TSA with usual care vs. 12 weeks of supervised exercise (1 weekly session).
- Primary outcome: Patient-reported quality of life (WOOS score) at 12 months.
- Secondary outcomes: Pain intensity, DASH score, analgesic use, adverse events.
Main Results:
- Recruitment initiated April 2021, expected completion March 2024.
- Primary outcome data collection ongoing.
- Key secondary outcome data collection ongoing.
Conclusions:
- This RCT will provide crucial evidence on the comparative effectiveness of TSA versus exercise for glenohumeral OA.
- Findings will inform clinical decision-making for patients with primary glenohumeral OA.
- The study addresses a gap in the literature regarding direct comparison of surgical versus non-surgical management.
