Related Experiment Video

Updated: Oct 4, 2025

Cholesterol Efflux Assay
07:54

Cholesterol Efflux Assay

Published on: March 6, 2012

30.1K

Transintestinal cholesterol excretion in health and disease

Damien Garçon1, Jean-Matthieu Berger2, Bertrand Cariou1

  • 1Nantes Université, CHU Nantes*, CNRS, INSERM, l'institut du thorax, F-44000, Nantes, France.

Current Atherosclerosis Reports
|February 9, 2022
PubMed
Abstract

Insights

The transintestinal cholesterol efflux (TICE) pathway aids plasma cholesterol elimination. Inducing TICE offers a safer therapeutic target for cardiovascular disease than other methods.

Area of Science:

  • Cardiovascular Science
  • Metabolic Pathways
  • Cholesterol Homeostasis

Background:

  • The transintestinal cholesterol efflux (TICE) pathway is a key route for eliminating plasma cholesterol from the body.
  • While less significant than the hepatobiliary pathway under basal conditions, TICE can be modulated by various factors.
  • Understanding TICE is crucial for managing cholesterol metabolism and cardiovascular health.

Purpose of the Study:

  • To review recent advancements in transintestinal cholesterol efflux (TICE) research.
  • To explore TICE inducers, its molecular underpinnings, and its role in lipoprotein metabolism.
  • To highlight TICE as a potential therapeutic target for cardiovascular diseases.

Main Methods:

  • Review of current scientific literature on TICE.
  • Analysis of kinetic measurements and experimental data related to cholesterol efflux pathways.
  • Comparative assessment of TICE versus hepatobiliary cholesterol excretion.

Main Results:

  • TICE is an active pathway in humans, mice, and rats.
  • Nutritional factors and drugs can significantly induce TICE.
  • Unlike enhanced biliary excretion, TICE induction does not increase gallstone risk.
  • TICE plays a role in the anti-atherogenic reverse cholesterol pathway.

Conclusions:

  • TICE represents a promising and safer therapeutic target for managing plasma cholesterol levels.
  • Modulating TICE offers new strategies for preventing and treating cardiovascular diseases.
  • Further research into TICE mechanisms can unlock novel treatments for high-risk patients.
Keywords:
AtherosclerosisReverse cholesterol transportTransintestinal cholesterol efflux (TICE)

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