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[Developmental problems in prematures]

Anne M De Grauw1,2, Pauline E Van Beek3, Aleid G Leemhuis4

  • 1Hagaziekenhuis, locatie Juliana Kinderziekenhuis, den Haag, afd. Neonatologie.

Nederlands Tijdschrift Voor Geneeskunde
|February 9, 2022
PubMed

Insights

Premature infants born at 24-26 weeks

Area of Science:

  • Neonatalogy and Developmental Pediatrics
  • Public Health and Epidemiology

Background:

  • The EPIPAGE-2 study followed a cohort of extremely preterm infants.
  • Understanding long-term outcomes for premature infants is crucial for clinical practice and public health.
  • Socio-economic status (SES) is a known factor influencing child development and participation in studies.

Purpose of the Study:

  • To assess the neurodevelopmental outcomes at 5.5 years of age for children born prematurely (24-34 weeks' gestational age).
  • To investigate the impact of gestational age and socio-economic status on the outcomes of preterm infants.
  • To identify specific challenges and needs for follow-up programs for preterm infants, particularly those from lower SES backgrounds.

Main Methods:

  • Longitudinal cohort study of premature infants born between 24 and 34 weeks' gestational age.
  • Neurodevelopmental assessments at 5.5 years of corrected age.
  • Statistical analysis accounting for socio-economic status and imputation of missing data.

Main Results:

  • Survival rates increased with higher gestational age.
  • Among survivors born at 24-26 weeks' gestational age, 75% had no or mild impairment at 5.5 years.
  • Mild cognitive impairment and school problems were common across all gestational age groups.
  • Lower socio-economic status was associated with increased risk of developmental impairment.

Conclusions:

  • Gestational age and socio-economic status are critical determinants of neurodevelopmental outcomes in preterm infants.
  • Mild cognitive impairments and school difficulties are prevalent in this population.
  • Targeted follow-up programs and interventions are needed, especially for preterm infants from lower socio-economic backgrounds.

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