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Systemic Markers in Ophthalmic Manifestations of Post Corona Virus Disease-19 (COVID-19)

Srinivasan Sanjay1, Sai Bhakti Mistra1, Sithun Kumar Patro2

  • 1Department of Uveitis and Ocular Immunology, Narayana Nethralaya, Bangalore, India.

Ocular Immunology and Inflammation
|February 9, 2022
PubMed

Insights

Elevated D-dimer and ferritin levels correlate with sight-threatening ophthalmic manifestations in patients with a history of coronavirus disease (COVID-19). These markers indicate systemic inflammation post-COVID-19 infection.

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Systemic Manifestations

Background:

  • Coronavirus disease (COVID-19) is linked to various ophthalmic complications.
  • Understanding the systemic impact on ocular health is crucial for patient management.

Purpose of the Study:

  • To investigate the systemic status of ophthalmic patients with a history of COVID-19.
  • To identify potential biomarkers associated with ocular manifestations post-COVID-19.

Main Methods:

  • Retrospective case series involving 30 patients with a history of COVID-19 and positive antibodies.
  • Patients were categorized into two groups based on visual acuity (VA).
  • Analysis of D-dimer, serum ferritin, ESR, and CRP levels.

Main Results:

  • Higher D-dimer (p=0.013) and serum ferritin (p=0.018) levels were observed in patients with poorer visual acuity (VA < 6/60).
  • Elevated ESR and CRP levels were noted even after COVID-19 recovery, though not statistically significant.
  • These findings suggest a link between specific inflammatory markers and ocular health outcomes.

Conclusions:

  • Serum D-dimer and ferritin levels are significantly higher in patients experiencing sight-threatening ocular manifestations following COVID-19.
  • Inflammatory markers like ESR and CRP may remain elevated post-recovery, indicating persistent systemic effects.
  • This study highlights the importance of monitoring systemic markers in ophthalmic patients with a history of COVID-19.
Abstract

Keywords:
COVID-19D-dimerSystemic markersophthalmic manifestationsserum ferritinsight threatening manifestations

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