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Emerging role of non-coding RNAs in the regulation of KRAS

Soudeh Ghafouri-Fard1, Zeinab Shirvani-Farsani2, Bashdar Mahmud Hussen3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cancer Cell International
|February 10, 2022
PubMed

Insights

The Kirsten ras oncogene (KRAS) interacts with various non-coding RNAs, including long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs). These interactions are significant in understanding and potentially treating various cancers.

Area of Science:

  • Molecular Biology
  • Oncology
  • Genetics

Background:

  • The Kirsten ras oncogene (KRAS) is a key regulator in the RAS/MAPK pathway, crucial for cell signaling.
  • Aberrant KRAS activation, often due to mutations, drives cell transformation and is implicated in numerous cancers.

Purpose of the Study:

  • To review the interactions between KRAS and different classes of non-coding RNAs.
  • To highlight the role of these interactions in cancer development and progression.

Main Methods:

  • Literature review of studies investigating KRAS interactions with non-coding RNAs.
  • Categorization of interacting non-coding RNAs into long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs).

Main Results:

  • Numerous lncRNAs, including MALAT1 and PCAT-1, have verified interactions with KRAS in cancer.
  • Specific miRNAs like miR-143 and miR-126 interact with KRAS.
  • Several circRNAs, such as circITGA7 and circFNTA, also demonstrate interactions with KRAS.

Conclusions:

  • Non-coding RNAs represent a significant layer of KRAS regulation.
  • Understanding these KRAS-non-coding RNA interactions is vital for advancing cancer diagnostics and therapeutics.
Keywords:
KRASOncogenecircRNAlncRNAmiRNA

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