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Cardio-Ankle Vascular Index is Associated with Prevalence and New-Appearance of Atrial Fibrillation in Japanese Urban

Daiji Nagayama1,2, Kentaro Fujishiro3, Keijiro Nakamura4

  • 1Department of Internal Medicine, Nagayama Clinic, Tochigi, Japan.

Vascular Health and Risk Management
|February 10, 2022
PubMed

Insights

Cardio-ankle vascular index (CAVI), a measure of arterial stiffness, is independently associated with atrial fibrillation (AF) in Japanese adults. Higher CAVI may indicate a modifiable risk factor for developing AF.

Area of Science:

  • Cardiovascular Medicine
  • Vascular Biology
  • Epidemiology

Background:

  • Systemic vascular function tests are not standard in atrial fibrillation (AF) risk assessment.
  • Cardio-ankle vascular index (CAVI) quantifies systemic arterial stiffness.

Purpose of the Study:

  • To investigate the association between CAVI and the presence of AF in a Japanese population.
  • To determine if CAVI is an independent predictor of new-onset AF.

Main Methods:

  • Cross-sectional study (N=47,687) and a 4-year cohort study (N=5418) of Japanese urban residents.
  • Propensity score matching, logistic regression, ROC curve analysis, and Cox-proportional hazards analysis were employed.

Main Results:

  • CAVI was independently associated with AF in cross-sectional analysis.
  • Higher baseline CAVI predicted new-onset AF in the cohort study (AUC=0.747, cut-off=8.0).
  • CAVI ≥8.0 was an independent predictor of new-onset AF.

Conclusions:

  • Elevated CAVI may be a significant, modifiable risk factor for AF development.
  • Further research is needed to confirm CAVI's predictive value and the efficacy of CAVI-lowering interventions for AF prevention.
Abstract

Keywords:
CAVIarterial stiffnessatrial fibrillationcardio-ankle vascular indexhealth screening

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