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p-Cresyl Sulfate Predicts Ischemic Stroke among Patients on Hemodialysis: A Prospective Cohort Study

Xiao Tan1, Jianzhou Zou2, Fangfang Xiang2

  • 1Department of Nephrology, Zhongshan Hospital, Fudan University, No. 180, Fenglin Road, Shanghai, China.

Disease Markers
|February 10, 2022
PubMed

Insights

Elevated plasma p-cresyl sulfate levels are linked to a higher risk of ischemic stroke in patients undergoing hemodialysis. This finding highlights p-cresyl sulfate as a potential predictor for stroke events in this population.

Area of Science:

  • Nephrology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Hemodialysis patients face increased risks for cardiovascular events.
  • Plasma p-cresyl sulfate is a uremic toxin with potential adverse health effects.

Purpose of the Study:

  • To investigate the association between plasma p-cresyl sulfate levels and the incidence of ischemic stroke.
  • To determine if p-cresyl sulfate can serve as a predictive biomarker for stroke in hemodialysis patients.

Main Methods:

  • Prospective cohort study involving hemodialysis patients.
  • Patients stratified into high and low plasma p-cresyl sulfate groups.
  • Kaplan-Meier analysis and Cox proportional hazard models used for association analysis.

Main Results:

  • Higher incidence of ischemic stroke observed in the high p-cresyl sulfate group (Log-Rank P = 0.007).
  • Plasma p-cresyl sulfate significantly associated with ischemic stroke risk (HR 2.332, P = 0.009).
  • Association remained significant after adjusting for confounding factors (HR 2.061, P = 0.041).

Conclusions:

  • Plasma p-cresyl sulfate is a significant predictor of first ischemic stroke incidence.
  • This finding supports the role of p-cresyl sulfate as a potential biomarker in hemodialysis patients.
Abstract

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