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Effect of Micronutrients on Thyroid Parameters.

Hari Krishnan Krishnamurthy1, Swarnkumar Reddy2, Vasanth Jayaraman1

  • 1Vibrant Sciences LLC., San Carlos, CA, USA.

Journal of Thyroid Research
|February 10, 2022
PubMed
Summary
This summary is machine-generated.

Micronutrient deficiencies, particularly vitamins B2, B12, B9, and Vitamin D, significantly impact thyroid function. Specific amino acids and minerals also show correlations with thyroid hormones like T3, T4, and TSH.

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Area of Science:

  • Endocrinology and Metabolism
  • Nutritional Science

Background:

  • Micronutrients play crucial roles in cellular metabolism, including thyroid hormone regulation.
  • Thyroid dysfunction can be influenced by nutritional status, highlighting the importance of micronutrient assessment.

Purpose of the Study:

  • To investigate the relationship between serum micronutrient levels and various thyroid markers in healthy individuals.
  • To identify specific micronutrients that correlate with thyroid hormone levels (T4, T3, FT4, FT3) and thyroid-stimulating hormone (TSH).

Main Methods:

  • Serum samples from 387 healthy individuals were analyzed for thyroid markers and a comprehensive micronutrient profile.
  • Participants were categorized into deficient, normal, or excess groups for each micronutrient.
  • Statistical analysis was performed to determine correlations between micronutrient status and thyroid parameters.

Main Results:

  • Deficiencies in Vitamin B2, B12, B9, and Vitamin D (25[OH]) were significantly associated with altered thyroid functioning (p < 0.05).
  • Elemental micronutrients including calcium, copper, choline, iron, and zinc showed significant correlation with free T3 levels (p < 0.05).
  • Amino acids asparagine and serine positively correlated with TSH (p < 0.001 and p < 0.05, respectively), while valine, leucine, and arginine correlated with T4 and FT4 (p < 0.05).

Conclusions:

  • Serum levels of specific vitamins, minerals, and amino acids are significantly associated with thyroid markers.
  • Particular attention should be paid to the impact of serum amino acid levels on thyroid hormone regulation.