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Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients
Published on: April 18, 2025
481
Hypotension in hereditary cardiomyopathy.
Johny Al-Khoury1, Danielle Jacques1, Ghassan Bkaily2
1Department of Immunology and Cell Biology, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, J1H 5N4, Canada.
Pflugers Archiv : European Journal of Physiology
|February 10, 2022
Summary
Hypotension, or low blood pressure, is linked to hereditary cardiomyopathy (HCM). Blocking the NHE1 protein partially reversed this hypotension, suggesting it as a potential biomarker for HCM progression to heart failure.
Area of Science:
- Cardiology
- Genetics
- Physiology
Background:
- Hypertension is a known risk factor for heart failure (HF).
- The role of hypotension in hereditary cardiomyopathy (HCM) onset and progression to HF remains unclear.
- HCM can lead to heart failure and premature death.
Purpose of the Study:
- To investigate blood pressure changes during different stages of HCM.
- To determine if hypotension contributes to HCM progression.
- To explore the role of the sodium-hydrogen exchanger 1 (NHE1) in HCM-associated hypotension.
Main Methods:
- Utilized the UM-X7.1 hamster model of HCM (HCMH).
- Monitored mean arterial pressure (MAP) across HCM phases: asymptomatic, necrosis, hypertrophy, and heart failure.
- Administered the NHE1 inhibitor EMD 87580 (rimeporide) to assess its effect on MAP in HCMH and normal hamsters (NH).
Main Results:
- No significant MAP change in asymptomatic HCMH compared to NH.
- Progressive MAP decrease observed in HCMH, reaching lowest levels during heart failure.
- MAP reduction during necrosis phase correlated with increased NHE1 levels.
- EMD 87580 treatment reversed hypotension in HCMH but did not affect NH MAP.
- NHE1 inhibition partially mitigated hypotension, indicating other contributing mechanisms.
Conclusions:
- HCM development is associated with hypotension.
- Decreased blood pressure may serve as a biomarker for HCM progression to heart failure.
- NHE1 plays a role in HCM-related hypotension, but other pathways are also involved.
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