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Poorly controlled hypertension is associated with elevated serum uric acid to HDL-cholesterol ratio: a

Gulali Aktas1, Atiqa Khalid2, Ozge Kurtkulagi1

  • 1Department of Internal Medicine, Abant Izzet Baysal University Hospital, Bolu, Turkey.

Postgraduate Medicine
|February 10, 2022
PubMed

Insights

The uric acid/HDL-cholesterol ratio (UHR) is significantly higher in patients with poorly controlled hypertension. Elevated UHR is an independent risk factor for poor blood pressure control in hypertension patients.

Area of Science:

  • Cardiology
  • Metabolic Syndrome
  • Hypertension Research

Background:

  • Accurate blood pressure measurement is crucial for hypertension (HT) diagnosis and management.
  • Several factors can influence blood pressure readings, necessitating reliable biomarkers for assessing HT control.

Purpose of the Study:

  • To investigate the role of the uric acid/HDL-cholesterol ratio (UHR) in hypertension.
  • To determine if UHR is associated with poor blood pressure control in hypertensive individuals.

Main Methods:

  • A retrospective cross-sectional cohort study involving 535 participants.
  • Hypertensive patients were categorized into well-controlled, poorly controlled groups, with healthy volunteers as a control group.
  • Comparison of UHR levels across the study groups based on Joint National Committee VIII criteria.

Main Results:

  • Median UHR was significantly higher in the poorly controlled HT group (13%) compared to the well-controlled HT group (11%) and control group (8%).
  • UHR showed a positive correlation with both systolic (r=0.33) and diastolic (r=0.28) blood pressure.
  • An elevated UHR (>11%) demonstrated 70% sensitivity and 60% specificity for predicting poor BP control (AUC: 0.73).
  • UHR was identified as an independent risk factor, with each unit increase elevating the risk of poorer BP control by 7.3 times.

Conclusions:

  • Elevated UHR levels are significantly associated with poor blood pressure control in hypertensive patients.
  • UHR assessment may serve as a valuable tool for identifying individuals at risk of inadequate hypertension management.
  • Further research into UHR as a biomarker for hypertension control is warranted.
Abstract

Keywords:
Uric acid to HDL ratioblood pressurefollow-uphypertension

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