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Updated: Oct 4, 2025

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
Published on: October 12, 2018
Genital Immune Cell Activation and Tenofovir Gel Efficacy: A Case-Control Study
Lenine J P Liebenberg1,2, Jo Ann S Passmore1,3,4, Farzana Osman1
1Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
None:
Genital inflammation (GI) undermines topical human immunodeficiency virus (HIV) pre-exposure prophylaxis (PrEP) efficacy through unknown mechanisms. Here, associations between activated endocervical CD4 + T-cell numbers and higher deoxyadenosine triphosphate (dATP) concentrations suggest that competition for intracellular metabolites within HIV target cells may reduce the efficacy of antiretroviral-based PrEP in women with GI.

