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Pretreatment patient-reported cognitive function in patients with diffuse glioma.
Stine Schei1,2, Ole Solheim3,4, Øyvind Salvesen5
1Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. stine.schei@ntnu.no.
Acta Neurochirurgica
|February 10, 2022
Summary
Patient-reported cognitive impairment is common in diffuse glioma patients before treatment, occurring nearly twice as often as in controls. Factors like large tumor size and lower performance status predict this impairment.
Area of Science:
- Neuro-oncology
- Patient-reported outcomes
- Cognitive science
Background:
- Objective neuropsychological tests are standard for assessing cognitive function.
- Patient-reported cognitive function in diffuse glioma is less explored.
- Understanding subjective cognitive experiences is crucial for comprehensive patient care.
Purpose of the Study:
- To determine the prevalence of patient-reported cognitive impairment in diffuse glioma patients preoperatively.
- To compare this prevalence against a matched reference group.
- To identify factors associated with patient-reported cognitive impairment.
Main Methods:
- A cohort of 237 diffuse glioma patients and 474 matched controls was analyzed.
- Patient-reported cognitive function was assessed using the EORTC QLQ-C30 questionnaire.
- Cognitive impairment was defined as a score ≤75; multivariable regression identified associated factors.
Main Results:
- Nearly half (49.8%) of diffuse glioma patients reported cognitive impairment versus 23.4% in controls (p < 0.001).
- Diffuse glioma patients had over three times higher odds of reporting cognitive impairment.
- Large tumor volume, left-sided tumors, and low Karnofsky Performance Status independently predicted impairment.
Conclusions:
- Patient-reported cognitive impairment is highly prevalent in diffuse glioma patients before treatment.
- Findings highlight the importance of subjective cognitive assessment, especially with specific tumor characteristics.
- Patient-reported data can complement objective testing and aid in screening.
