Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

11
Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
11
Naturalistic Observations02:30

Naturalistic Observations

16.5K
If you want to understand how behavior occurs, one of the best ways to gain information is to simply observe the behavior in its natural context. However, people might change their behavior in unexpected ways if they know they are being observed. How do researchers obtain accurate information when people tend to hide their natural behavior? As an example, imagine that your professor asks everyone in your class to raise their hand if they always wash their hands after using the restroom. Chances...
16.5K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

8
In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
8
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

9
Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
9
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

16
In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
16
Understanding Deception01:14

Understanding Deception

13
Deception is a pervasive aspect of human communication. Empirical studies have shown that most individuals engage in some form of deceit on a daily basis, with approximately 20% of social exchanges involving deceptive elements. Lying follows a developmental trajectory, peaking during adolescence and declining with age, possibly due to the maturation of cognitive control and social accountability.Cognitive and Social Factors in Deception DetectionDespite its prevalence, accurately detecting...
13

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mistaking Conscience for Control: Why Institutional Conscience Claims are an Unethical Gambit.

The American journal of bioethics : AJOB·2026
Same author

AI Ethics 2.0: Why Frontier AI Demands a New Governance Agenda for Healthcare.

The American journal of bioethics : AJOB·2026
Same author

Do Reasons Matter? An Empirical Exploration of the Role of Parents' Reasons in Treatment Refusal in Pediatric Oncology.

AJOB empirical bioethics·2026
Same author

What Can We Ask of Hospitals? Conceptual Foundations for an Ethics of Healthcare Organizations.

The American journal of bioethics : AJOB·2026
Same author

The Ordinary Experience of Choosing to Parent Extraordinary Children.

Narrative inquiry in bioethics·2026
Same author

Stakeholder Perspectives on Humanistic Implementation of Computer Perception in Health Care: Qualitative Study.

JMIR mental health·2026
Same journal

Harm Reduction as an Alternative to Mandated Drug Treatment.

The Hastings Center report·2026
Same journal

Rethinking Mandated Drug Treatment: Why Expanding Freedom Requires Structural Drug Policy Reform.

The Hastings Center report·2026
Same journal

Banning Gender-Affirming Treatment for Minors: The Supreme Court Speaks.

The Hastings Center report·2026
Same journal

Making the Move to a Learning System of Research Ethics.

The Hastings Center report·2026
Same journal

Musical Performance and Biomedical Human Enhancement: Ethnographic Perspectives on Bioethical Questions.

The Hastings Center report·2026
Same journal

Transformed but Not Cured: The Ethics of Describing Gene-Editing Therapy for Sickle Cell Disease.

The Hastings Center report·2026
See all related articles

Related Experiment Video

Updated: Oct 4, 2025

The Modified Temptation Resistance Task: A Paradigm to Elicit Children's Strategic Lie-telling
06:51

The Modified Temptation Resistance Task: A Paradigm to Elicit Children's Strategic Lie-telling

Published on: April 6, 2018

8.6K

Pediatric Authenticity: Hiding in Plain Sight.

Ryan H Nelson, Bryanna Moore, Jennifer Blumenthal-Barby

    The Hastings Center Report
    |February 10, 2022
    PubMed
    Summary
    This summary is machine-generated.

    Pediatric decision-making often overlooks patient authenticity, focusing instead on best interests. This article introduces pediatric authenticity, emphasizing choices consistent with the child's identity, not just their preferences or medical needs.

    Keywords:
    assentauthenticitybest interestsclinical ethicsdecision-making for children and adolescentspediatrics

    More Related Videos

    An Experimental Analysis of Children's Ability to Provide a False Report about a Crime
    07:36

    An Experimental Analysis of Children's Ability to Provide a False Report about a Crime

    Published on: May 3, 2016

    8.6K
    Whole-body PET/MRI of Pediatric Patients: The Details That Matter
    10:02

    Whole-body PET/MRI of Pediatric Patients: The Details That Matter

    Published on: December 19, 2017

    14.8K

    Related Experiment Videos

    Last Updated: Oct 4, 2025

    The Modified Temptation Resistance Task: A Paradigm to Elicit Children's Strategic Lie-telling
    06:51

    The Modified Temptation Resistance Task: A Paradigm to Elicit Children's Strategic Lie-telling

    Published on: April 6, 2018

    8.6K
    An Experimental Analysis of Children's Ability to Provide a False Report about a Crime
    07:36

    An Experimental Analysis of Children's Ability to Provide a False Report about a Crime

    Published on: May 3, 2016

    8.6K
    Whole-body PET/MRI of Pediatric Patients: The Details That Matter
    10:02

    Whole-body PET/MRI of Pediatric Patients: The Details That Matter

    Published on: December 19, 2017

    14.8K

    Area of Science:

    • Bioethics
    • Pediatric Decision-Making
    • Medical Ethics

    Background:

    • Current pediatric decision-making frameworks balance patient interests with parental authority.
    • A crucial aspect, patient authenticity, is often neglected in these discussions.
    • Existing standards may not fully capture the child's unique identity in medical choices.

    Purpose of the Study:

    • To introduce and define the concept of pediatric authenticity in medical decision-making.
    • To explore how authenticity considerations can complement existing 'best interest' standards.
    • To differentiate pediatric authenticity from subjective interests and patient assent.

    Main Methods:

    • Philosophical analysis of authenticity within the pediatric context.
    • Review of existing ethical frameworks in pediatric decision-making.
    • Development of a novel account of pediatric authenticity.
    • Case study analysis to illustrate the application of pediatric authenticity.

    Main Results:

    • Patient authenticity offers a distinct ethical consideration beyond medical best interests or parental authority.
    • Authenticity highlights choices aligned with a child's core identity and values.
    • The proposed framework distinguishes authenticity from subjective interests and assent, clarifying its unique role.

    Conclusions:

    • Pediatric authenticity is a vital, often overlooked, ethical standard in medical decision-making.
    • Incorporating authenticity enriches the ethical evaluation of choices for pediatric patients.
    • The concept has significant normative implications across various pediatric medical scenarios.