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Related Concept Videos

Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Role of Skin in Vitamin D Synthesis01:23

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
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Introduction to Electrolytes01:33

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In humans, electrolytes play a vital role in various physiological processes. Balancing electrolyte levels is essential for normal body functions; their imbalance can be life-threatening. The major electrolytes include sodium, potassium, chloride, calcium, phosphate, and bicarbonate. They are primarily involved in physiological processes, such as nerve signal transmission, membrane trafficking, muscle contraction, buffering body fluids, and balancing water levels in the body.
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Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Related Experiment Video

Updated: Oct 4, 2025

Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts

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Nutritional rickets - Vitamin D and beyond.

Philip R Fischer1, Neamat I Almasri2

  • 1Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA; Department of Pediatrics, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Khalifa University, Abu Dhabi, United Arab Emirates.

The Journal of Steroid Biochemistry and Molecular Biology
|February 10, 2022
PubMed
Summary
This summary is machine-generated.

Nutritional rickets can result from vitamin D deficiency or inadequate calcium intake. These deficiencies interact, alongside other factors, in causing this bone disease.

Keywords:
BoneCalcium deficiencyMineralizationRicketsVitamin D

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Area of Science:

  • Pediatrics
  • Nutritional Science
  • Endocrinology

Background:

  • Historically, vitamin D deficiency was the sole recognized cause of nutritional rickets.
  • Recent research indicates that calcium deficiency is also a significant cause of nutritional rickets.
  • The interplay between vitamin D and calcium in rickets pathogenesis is increasingly understood.

Purpose of the Study:

  • To elucidate the multifactorial causes of nutritional rickets.
  • To highlight the role of calcium deficiency alongside vitamin D deficiency.
  • To discuss the interactive effects of nutritional deficiencies in rickets.

Main Methods:

  • Review of historical and contemporary research on nutritional rickets.
  • Analysis of etiological factors contributing to rickets development.
  • Examination of the pathophysiology of vitamin D and calcium deficiency.

Main Results:

  • Nutritional rickets is caused by either vitamin D deficiency or insufficient dietary calcium.
  • Combined deficiencies of vitamin D and calcium exacerbate the condition.
  • Other contributing factors influence the development of nutritional rickets.

Conclusions:

  • Nutritional rickets etiology is more complex than previously thought.
  • Dietary calcium intake is a critical factor in preventing rickets.
  • A comprehensive understanding of multiple factors is essential for managing nutritional rickets.