Related Experiment Video

Updated: Oct 4, 2025

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

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Severe varicella in a child immunosuppressed with methotrexate

Letícia Oba Galvão1, Carmelia Matos Santiago Reis1, Natália Lima Alves1

  • 1Dermatology Service, Hospital Regional da Asa Norte, Brasília, DF, Brazil.

Anais Brasileiros De Dermatologia
|February 11, 2022
PubMed

Insights

Severe varicella infection can occur in children using methotrexate, an immunosuppressive drug. Vaccination is recommended to prevent severe cases of chickenpox in immunocompromised children.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • Varicella (chickenpox) is typically a mild childhood illness.
  • Immunosuppressed children face increased risk of severe varicella.
  • Methotrexate is an immunosuppressive drug used for inflammatory conditions.

Keywords:
ImmunosuppressionMethotrexatePsoriasisVaricella

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