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Recurrent thrombosis as a clinical presentation of Whipple disease

María Terrones-Peinador1, Simeón Eremiev-Eremiev2, Carlos Pigrau-Serrallach2

  • 1Internal Medicine Department, Vall d'Hebron University Hospital, Barcelona, Catalunya, Spain mterrones@vhebron.net.

BMJ Case Reports
|February 11, 2022
PubMed

Insights

Whipple's disease (WD) can cause recurrent blood clots, even with anticoagulation. Early diagnosis and treatment of WD resolved fever and thrombosis in a rare case.

Area of Science:

  • Infectious Diseases
  • Hematology
  • Gastroenterology

Background:

  • Whipple's disease (WD) is a rare systemic infection with diverse clinical presentations.
  • Thrombotic events are infrequently associated with WD, typically presenting as stroke-like syndromes.

Observation:

  • A 39-year-old male experienced recurrent fevers, generalized adenopathy, and multiple superficial and deep venous thromboses over one year.
  • The thrombotic events persisted despite multiple anticoagulation treatments.

Findings:

  • The patient was ultimately diagnosed with Whipple's disease.
  • Successful antibiotic treatment for WD led to complete resolution of fever and thrombotic episodes.

Implications:

  • This case highlights an unusual presentation of Whipple's disease involving significant thrombotic manifestations.
  • It underscores the importance of considering WD in patients with unexplained recurrent thrombosis and fever.
  • Effective treatment of Whipple's disease can resolve associated thrombotic complications.
Keywords:
bone and joint infectionshaematology (incl blood transfusion)infection (gastroenterology)

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