A Guideline for Clinicians Performing Clinical Studies with Fluorescence Imaging

Area of Science:

• Medical imaging
• Biotechnology
• Clinical research

Background:

• Fluorescence imaging is a rapidly advancing technique with significant clinical benefits.
• The field is experiencing rapid clinical translation, leading to numerous ongoing clinical trials.
• Clinicians face challenges in navigating diverse imaging modalities and combinations.

Purpose of the Study:

• To outline essential components for a uniform fluorescence imaging protocol.
• To ensure consistent study designs and reliable data collection in clinical trials.
• To facilitate the integration of fluorescence imaging into standard clinical care.

Main Methods:

• Discussing key elements for a standardized fluorescence imaging protocol.
• Highlighting the need for a multidisciplinary approach involving drug discovery, software engineering, and translational medicine.
• Emphasizing consistent study conduct, data analysis, and interpretation.

Main Results:

• Identified critical factors for developing a uniform fluorescence imaging protocol.
• Proposed a framework for multidisciplinary collaboration to address clinical needs.
• Stressed the importance of consistency for reliable data in clinical trials.

Conclusions:

• A uniform fluorescence imaging protocol is essential for successful clinical translation.
• Multidisciplinary collaboration is key to optimizing fluorescence imaging in clinical practice.
• Consistent data collection and interpretation are vital for adopting fluorescence imaging as a standard of care.