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Lamina-associated polypeptide 2α is required for intranuclear MRTF-A activity.

Ekaterina Sidorenko1, Maria Sokolova1, Antti P Pennanen1

  • 1Institute of Biotechnology, University of Helsinki, Helsinki, Finland.

Scientific Reports
|February 11, 2022
PubMed
Summary

Lamina-associated polypeptide 2α (Lap2α) is a novel nuclear regulator of Myocardin-related transcription factor A (MRTF-A). Lap2α is essential for MRTF-A/SRF target gene expression and serum-induced cell migration.

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